Decreased oxygen utilization at the tissue level can occur in conditions such as:

Decreased oxygen utilization at the tissue level is prominently seen in cyanide toxicity. Cyanide is a potent metabolic poison that inhibits cellular respiration, specifically by binding to cytochrome c oxidase, an essential component of the mitochondrial electron transport chain. This action prevents cells from using oxygen effectively, despite the presence of oxygen in the bloodstream. As a result, tissues are unable to utilize oxygen for ATP production, leading to cellular asphyxiation.

In contrast, hyperthermia primarily affects the body's metabolic processes and can increase oxygen demand but does not directly impede oxygen utilization at the tissue level. Hemoconcentration, which entails a decrease in plasma volume leading to increased red blood cell concentration, may enhance oxygen delivery to tissues, but it does not decrease the tissues' ability to utilize oxygen. Fluid overload can lead to pulmonary congestion and impaired gas exchange in the lungs, but it does not directly impact the utilization of oxygen at the cellular level like cyanide does.